Otoxia 90 Tablet belongs to a group of medications called ‘non-steroidal anti-inflammatory drugs (NSAIDs) used to treat pain, swelling and inflammation in the conditions of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and gout in people with greater than 16 years of age. Besides this, it is also used to treat moderate pain after dental surgery. Osteoarthritis is a degenerative bone disease in which the tissue supporting the joints wears down. Rheumatoid arthritis is a condition in which the immune system attacks its own tissue leading to joint pain and inflammation. Ankylosing spondylitis is the inflammation of the spine and large joints. Gout is characterized by pain and inflammation in the joints due to the deposition of uric acid crystals.

Otoxia 90 Tablet contains ‘etoricoxib’ which is a non-steroidal anti-inflammatory drug (NSAID). It acts as both analgesic (reduce pain) and an anti-inflammatory (reduce inflammation) agent. It is a selective COX-2 inhibitor. COX-2 enzymes are responsible for converting arachidonic acid to prostaglandins that are inflammatory mediators. The blocking of COX-2 reduces the production of prostaglandins, eventually decreasing pain and inflammation. The benefit of COX-2 inhibitors is that they protect the stomach lining from the ulcer effect caused by other pain killers, ibuprofen and aspirin.

• Osteoarthritis
• Rheumatoid arthritis
• Ankylosing spondylitis
• Gout

Otoxia 90 Tablet is swallowed as a whole with a glass of water. Do not crush, chew or break them. The dose and duration are prescribed by your doctor. It is usually taken with or without food. However, the onset of action is faster when taken without food. It is advisable to take tablets at a fixed time every day.

Store in a cool and dry place away from sunlight

• Oral ulcer
• Bronchospasm
• Increased liver enzymes
• Esophagitis
• Stomach pain
• Diarrhea

Drug Warnings
Before taking Otoxia 90 Tablet, inform your doctor if you have a history of stomach bleeding or ulcer, liver or kidney diseases, dehydration because of prolonged vomiting or diarrhoea and swelling due to fluid retention. Inform your doctor if you have high blood pressure that is not treated or controlled as Otoxia 90 Tablet may increase blood pressure in some cases. Do not take Otoxia 90 Tablet if you are treated for infection as Otoxia 90 Tablet can mask fever (a sign of infection). Do not take Otoxia 90 Tablet if you smoke, have diabetes (high blood sugar), or high cholesterol as Otoxia 90 Tablet increases the risk of heart attack or stroke. Avoid lying down for at least half an hour after using Otoxia 90 Tablet. People who have had any heart attack and stroke in the past should not take Otoxia 90 Tablet. 

Drug Interactions
Drug-drug interactions: Otoxia 90 Tablet may interact with anticoagulant (warfarin and aspirin), antibiotic (rifampicin), immunosuppressant (methotrexate), antihypertensives (enalapril, ramipril, losartan, valsartan, and minoxidil), diuretics, antiarrhythmic drug (digoxin), anti-asthmatic drug (salbutamol) and oral contraceptives.

Drug-food interactions: No interactions found.

Drug-disease interactions: Otoxia 90 Tablet should be used with caution in patients with stomach ulcers or bleeding, severe kidney disease, liver diseases, colitis (inflammation of the large intestine), uncontrolled blood pressure, heart failure, stroke, and other heart problems.